Peter J Crouch Selected Research

CuATSM

1/2021	CuATSM improves motor function and extends survival but is not tolerated at a high dose in SOD1G93A mice with a C57BL/6 background.
5/2016	Copper delivery to the CNS by CuATSM effectively treats motor neuron disease in SOD(G93A) mice co-expressing the Copper-Chaperone-for-SOD.

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Peter J Crouch Research Topics

Disease

23	Alzheimer Disease (Alzheimer's Disease) 08/2021 - 01/2005
20	Amyotrophic Lateral Sclerosis (Lou Gehrig's Disease) 01/2022 - 01/2008
17	Neurodegenerative Diseases (Neurodegenerative Disease) 08/2021 - 08/2006
11	Neoplasms (Cancer) 08/2021 - 01/2008
7	Parkinson Disease (Parkinson's Disease) 10/2015 - 01/2008
6	Cognitive Dysfunction 08/2021 - 11/2007
6	Frontotemporal Lobar Degeneration (Degeneration, Frontotemporal Lobar) 01/2017 - 05/2010
5	Motor Neuron Disease (Primary Lateral Sclerosis) 05/2016 - 03/2012
4	Neuroblastoma 04/2019 - 01/2008
4	Amyloid Plaque 06/2010 - 08/2006
3	Inflammation (Inflammations) 01/2022 - 04/2014
3	Disease Progression 01/2021 - 04/2010
3	Frontotemporal Dementia (Semantic Dementia) 01/2017 - 03/2012
3	Neuronal Ceroid-Lipofuscinoses (Neuronal Ceroid Lipofuscinosis) 04/2014 - 01/2013
2	Iron Overload 01/2022 - 01/2021
2	Huntington Disease (Huntington's Disease) 01/2016 - 08/2014
2	Hypoxia (Hypoxemia) 10/2015 - 12/2011
1	Fibrosis (Cirrhosis) 01/2022
1	Muscular Dystrophies (Muscular Dystrophy) 01/2022
1	Duchenne Muscular Dystrophy (Muscular Dystrophy, Becker) 01/2022
1	Body Weight (Weight, Body) 12/2021
1	Bipolar Disorder (Manic Depressive Psychosis) 12/2021
1	Atrophy 10/2021
1	Memory Disorders (Memory Loss) 08/2021
1	Central Nervous System Diseases (CNS Diseases) 01/2021
1	Reperfusion Injury 01/2021
1	Muscular Atrophy (Muscle Atrophy) 01/2021
1	Restless Legs Syndrome (Restless Legs) 01/2021
1	Bites and Stings (Sting) 10/2020
1	Squamous Cell Carcinoma (Epidermoid Carcinoma) 04/2019
1	Nervous System Diseases (Neurological Disorders) 01/2017
1	Spinal Muscular Atrophy (Progressive Muscular Atrophy) 01/2016
1	Renal Cell Carcinoma (Grawitz Tumor) 10/2015

Drug/Important Bio-Agent (IBA)

19	MetalsIBA 01/2017 - 10/2006
15	CopperIBA 01/2021 - 10/2006
13	Proteins (Proteins, Gene)FDA Link 01/2022 - 08/2006
9	Amyloid beta-PeptidesIBA 06/2010 - 01/2005
8	IronIBA 01/2022 - 10/2006
8	Trace Elements (Biometals)IBA 04/2014 - 10/2006
7	Superoxide Dismutase-1IBA 01/2022 - 06/2014
6	ZincIBA 01/2021 - 10/2006
6	copper (II) diacetyl- di(N(4)- methylthiosemicarbazone)IBA 04/2019 - 02/2011
5	Amyloid (Amyloid Fibrils)IBA 03/2019 - 08/2006
5	DNA-Binding Proteins (DNA Binding Protein)IBA 01/2017 - 01/2013
5	LigandsIBA 10/2015 - 11/2007
4	EnzymesIBA 01/2022 - 09/2012
4	Peptides (Polypeptides)IBA 03/2019 - 01/2008
3	Biomarkers (Surrogate Marker)IBA 08/2021 - 04/2010
3	DNA (Deoxyribonucleic Acid)IBA 10/2020 - 02/2010
3	RNA-Binding Proteins (RNA-Binding Protein)IBA 01/2017 - 01/2013
3	Clioquinol (Vioform)FDA Link 01/2014 - 01/2008
3	IonsIBA 09/2012 - 03/2011
3	Coordination ComplexesIBA 10/2011 - 11/2009
2	DeferiproneIBA 01/2022 - 01/2021
2	Messenger RNA (mRNA)IBA 01/2022 - 06/2013
2	Reactive Oxygen Species (Oxygen Radicals)IBA 01/2022 - 01/2008
2	Pharmaceutical PreparationsIBA 01/2021 - 08/2007
2	CuATSMIBA 01/2021 - 05/2016
2	AntioxidantsIBA 01/2017 - 05/2015
2	LipidsIBA 04/2014 - 01/2008
2	IonophoresIBA 01/2014 - 03/2011
2	Amino Acids FDA Link 01/2008 - 10/2006
1	Ferritins (Ferritin)IBA 01/2022
1	DystrophinIBA 01/2022
1	Heme (Haem)IBA 01/2022
1	MyoglobinIBA 01/2022
1	LithiumIBA 12/2021
1	Lithium ChlorideIBA 12/2021
1	HepcidinsIBA 01/2021
1	Isoflurophate (DFP)FDA Link 01/2021
1	Small Interfering RNA (siRNA)IBA 01/2021
1	Serine Proteases (Serine Protease)IBA 01/2021
1	1- Methyl- 4- phenyl- 1,2,3,6- tetrahydropyridine (MPTP)IBA 10/2020
1	cyclic guanosine monophosphate-adenosine monophosphateIBA 10/2020
1	Interferon Type IIBA 10/2020
1	Mitochondrial DNA (mtDNA)IBA 10/2020
1	Adenosine Monophosphate (AMP)IBA 10/2020
1	CytokinesIBA 10/2020
1	Guanosine Monophosphate (5' Guanylic Acid)IBA 10/2020
1	PolyaminesIBA 04/2019
1	Biological ProductsIBA 04/2019
1	EthaneIBA 04/2019
1	Copper-64IBA 03/2019
1	Heterogeneous-Nuclear Ribonucleoprotein KIBA 01/2017
1	Acetylcysteine (Siran)FDA LinkGeneric 01/2016
1	Technetium (Technetium 99m)IBA 10/2015
1	RheniumIBA 10/2015
1	NitroimidazolesIBA 10/2015
1	(2,3-butanedione bis(N(4)- dimethylthiosemicarbazone))zinc(II)IBA 09/2015
1	MetalloproteinsIBA 09/2015
1	collapsin response mediator protein-2IBA 08/2014
1	Glycogen Synthase (Synthase I)IBA 08/2014
1	Huntingtin ProteinIBA 08/2014
1	LipofuscinIBA 04/2014
1	Therapeutic UsesIBA 12/2013
1	Progesterone FDA LinkGeneric 09/2013
1	Deferasirox FDA Link 07/2013
1	Chelating AgentsIBA 07/2013

Therapy/Procedure

5	Therapeutics 01/2021 - 08/2007
1	Laser Therapy (Surgery, Laser) 08/2016